n today’s busy life, more often than not we come across situations in which we just can’t afford any inefficiency in our work. We may need to attend a business meeting or give a very important presentation, but swelling, stiffness or other joint pain (symptoms of arthritis) might prevent us from doing so. In these situations, the need for a quick drug, that can relieve the pain and make us agile, is felt deeply. Celebrex is one such drug. It helps relieve pain and swelling and enables us to make that very important presentation in the office or undertake some other important task.
Celebrex is a fast acting drug. It relieves pain within a few hours and provides 24-hour pain relief. It gives you enough time to finish up your important task and make it to your physician for a thorough checkup. Body pain is caused by the release of certain chemicals. These chemicals are released by an enzyme known as Cyclo-oxygenase. Celebrex is also known as “COX II inhibitor” because it inhibits Cyclo-oxygenase-2, which is the enzyme that produces prostaglandin (a chemical in the body that causes pain). By suppressing the production of this substance, Celebrex significantly reduces pain – thus allowing you to work normally and finish up your assignments.
Celebrex was developed by G.D. Searle & Company, and is currently being manufactured by Pifzer. It has an effective dosage around 200-400mg per day, however the lowest effective dose should be used, as its use in excess can be very harmful. It is a relatively new non-steroidal anti-inflammatory drug (NSAID) and contains the active ingredient called celecoxib. Celebrex does not affect Cyclo-oxygenase-1, hence it has less side effects on the stomach (such as gastrointestinal ulceration), compared to other pain relieving dugs.
Like other NSAID drugs, this one also has adverse effects on the heart. People using this drug have a higher chance of heart attack or stroke. The cardiovascular hazards of Celebrex are still somewhat controversial. Data from different clinical tests has shown dissimilar results. According to one study prolonged usage of the drug does increase the risks of heart attack and stroke. This drug also contains sulfonamide, hence it can cause reactions in people who are allergic to drugs containing sulfonamide.
Celebrex has also shown that it acts as a reducing agent for certain cancers, particularly colorectal cancers. However its use as a cancer treatment drug is still controversial because of its harmful effects on the heart and blood circulatory system. This drug should not be used excessively without a physician’s advice.
This article is for informational purposes only. For further instructions on Celebrex consult with your doctor.
Possible side effects:
- indigestion and abdominal pain